DelveInsight’s, “Metastatic Colorectal Cancer Pipeline Insight 2023,” report provides comprehensive insights about 140+ companies and 140+ pipeline drugs in the Metastatic Colorectal Cancer pipeline landscape. It covers the Metastatic Colorectal Cancer pipeline drug profiles, including Metastatic Colorectal Cancer clinical trial and nonclinical stage products. It also covers the Metastatic Colorectal Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
For Metastatic Colorectal Cancer Emerging drugs, the Metastatic Colorectal Cancer pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Metastatic Colorectal Cancer pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.
In the Metastatic Colorectal Cancer Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Metastatic Colorectal Cancer clinical trials studies, Metastatic Colorectal Cancer NDA approvals (if any), and product development activities comprising the technology, Metastatic Colorectal Cancer collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.
Key takeaways from the Metastatic Colorectal Cancer Pipeline Report
To explore more information on the latest breakthroughs in the Metastatic Colorectal Cancer treatment landscape of the report, click here @ Metastatic Colorectal Cancer Pipeline Outlook
Metastatic Colorectal Cancer Overview
Colorectal cancer (CRC) is the third most common, with metastasis being the major cause of death in the majority of patients. Common sites of distant metastasis are the liver and the peritoneum. CRC starts in the colon or the rectum. These cancers can also be called colon cancer or rectal cancer, depending on where they start. Colon cancer and rectal cancer are often grouped because they have many features in common.
Recent Developmental Activities in the Metastatic Colorectal Cancer Treatment Landscape
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Metastatic Colorectal cancer Emerging Drugs Profile
Corsela (Trilaciclib) is a small-molecule, short-acting, inhibitor of cyclin-dependent kinases (CDK) 4 and 6 developed by G1 Therapeutics for its myeloprotection and potential antitumor efficacy and safety benefits in combination with cancer chemotherapy. CDKs govern cell cycle progression, and trilaciclib induces a transient, reversible G1 cell cycle arrest of proliferating hematopoietic stem and progenitor cells in bone marrow, thus protecting them from damage during chemotherapy. It is a novel therapeutic approach, which is given before chemotherapy that temporarily blocks progression through the cell cycle. This provides two benefits. First, it proactively helps protect HSPCs in bone marrow leading to preservation of neutrophils, erythrocytes, and platelets (called myeloprotection) which reduces the occurrences and severity of neutropenia and other myelosuppressive consequences of chemotherapy.
Famitinib is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Famitinib binds to and inhibits several RTKs, dysregulated in a variety of tumors, including stem cell factor receptor (c-Kit; SCFR), vascular endothelial growth factor receptor (VEGFR) 2 and 3, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinases Flt1 and Flt3. Inhibition of these RTKs may result in an inhibition of tumor growth and angiogenesis, and eventually tumor regression in tumor cells overexpressing these RTKs. Famitinib is being evaluated in Phase III clinical trial to treat metastatic colorectal cancer.
CMAB009 is a recombinant, human/mouse chimeric monoclonal antibody (mAb) that binds specifically to the extracellular domain of EGFR. It is composed of the Fv regions of a murine anti-EGFR antibody with human IgG1 heavy and k light chain constant regions and it is expressed by Chinese hamster ovary cells. It has the same amino acid sequence as cetuximab (C225, Erbitux®) , but it has slightly different abilities for glycosylation and other post-translational modifications, and it is developed by Shanghai Zhangjiang Biotechnology Limited Company and produced by Biomabs. Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). CMAB009, a recombinant anti-EGFR monoclonal antibody with the same amino acid sequence as cetuximab is being evaluated in a Phase III study to treat metastatic colorectal cancer.
Trastuzumab deruxtecan is a HER2 directed antibody drug conjugate (ADC). Designed using Daiichi Sankyo’s proprietary DXd ADC technology, trastuzumab deruxtecan is the lead ADC in the oncology portfolio of Daiichi Sankyo and the most advanced program in AstraZeneca’s ADC scientific platform. ADCs are targeted cancer medicines that deliver cytotoxic chemotherapy (“payload”) to cancer cells via a linker attached to a monoclonal antibody that binds to a specific target expressed on cancer cells. Trastuzumab deruxtecan is comprised of a HER2 monoclonal antibody attached to a novel topoisomerase I inhibitor payload by a tetrapeptide-based linker.
Scandion Oncology’s leading product – SCO101 – is ingested as a capsule and has in preclinical studies shown to significantly improve the effect of standard cancer treatment when given in combination with the cancer drug. Moreover, SCO-101 inhibits key resistance mechanisms that allow the standardized cancer treatment to be effective again in patients with drug resistant disease. Therefore, SCO-101 has the potential to make the chemotherapy much more effective without increasing side effects for patients. The target indications are metastatic colorectal cancer and inoperable or metastatic pancreatic cancer, with more indications likely to follow. Currently it is being evaluated in Phase II stage of development to treat patients with metastatic colorectal cancer.
Avotaciclib (formerly BEY 1107) is a CDK1 inhibitor being developed by BeyondBio for the treatment of pancreatic cancer and glioblastoma. The drug induces apoptosis through cell suicide mechanism by synchronizing the G2/M cell cycle phases of the glioblastoma and pancreatic cancer cells. Currently it is being evaluated in Phase I/II stage of development to treat metastatic colorectal cancer.
Etrumadenant (AB928), the first dual A2a/A2b adenosine receptor antagonist in the clinic, is designed to maximally inhibit the adenosine-driven impairment of tumor-infiltrating lymphocytes (mainly CD8+ T cells and NK cells) and myeloid cells (dendritic cells, macrophages), mediated by A2aR and A2bR, respectively. A2bR is also upregulated by certain cancer cells, such as in prostate cancer and KRAS- mutated cancers. As a result, Etrumadenant may uniquely block adenosine’s immunosuppressive and cancer cell-intrinsic effects. Developed specifically for the oncology setting, Etrumadenant achieves high penetration of tumor tissue, robust potency in the presence of high adenosine concentrations, and minimal shift in potency from non-specific protein binding. Etrumadenant has demonstrated a favorable safety profile with a variety of combination regimens and exhibits pharmacokinetics / pharmacodynamics consistent with once-daily dosing. AB928 is currently being evaluated in several Phase I/II studies across multiple indications including metastatic colorectal cancer.
Metastatic Colorectal Cancer Pipeline Therapeutics Assessment
There are approx. 140+ key companies which are developing the therapies for Metastatic Colorectal cancer. The companies which have their Metastatic Colorectal cancer drug candidates in the most advanced stage, i.e. phase III include, G1 Therapeutics.
For further information, refer to the detailed Metastatic Colorectal Cancer Unmet Needs, Metastatic Colorectal Cancer Market Drivers, and Metastatic Colorectal Cancer Market Barriers, click here @ Metastatic Colorectal Cancer Ongoing Clinical Trial Analysis
Scope of the Metastatic Colorectal Cancer Pipeline Report
Dive deep into rich insights for drugs for Metastatic Colorectal Cancer Pipeline Companies and Therapies, click here @ Metastatic Colorectal Cancer Unmet Needs and Analyst Views
Table of Content
Got Queries? Find out the related information on Metastatic Colorectal cancer Mergers and acquisitions, Metastatic Colorectal cancer Licensing Activities @ Metastatic Colorectal cancer Emerging Drugs, and Recent Trends
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